The Correlation Between PARP1 and BRCA1 in AR Positive Triple-negative Breast Cancer
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چکیده
منابع مشابه
The Correlation Between PARP1 and BRCA1 in AR Positive Triple-negative Breast Cancer
Triple-negative breast cancer (TNBC) lacks estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2) expression and thus cannot benefit from conventional hormonal or anti-HER2 targeted therapies. Anti-androgen therapy has shown a certain effect on androgen receptor (AR) positive TNBC. The emerging researches have proved that poly (ADP-ribose) polyme...
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Background: Previous studies have suggested that BRCA1 dysregulation has been shown to have a role in triple-negative phenotypic manifestation. However, differences of BRCA1 expression, as a tumor suppressor gene, have rarely been investigated between luminal and triple-negative breast tumors. Therefore, the present study attempted to compare the BRCA1 expression in triple-negative with lu...
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Material and methods 332 unselected patients with invasive breast cancer diagnosed between 20062011 were identified from Pauls Stradins Clinical University Hospital, Riga East University hospital databases and clinical data from medical records were retrospectively analyzed. All patients were tested for the two common founder mutations in BRCA1 (4153delA and 5382insC) in Latvia using a multiple...
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Background: Previous data have shown the tumorigenicity roles of HDAC8 in breast cancer. More recently, the oncogenic effects of this molecule have been revealed in TNBC. The present study aimed to determine the diagnostic value of HDAC8 for the differentiation of TNBC from nTNBC tumors. Methods: A total of 50 cancerous and normal adjacent tumor specimens were obtained, and the clinical and pat...
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ژورنال
عنوان ژورنال: International Journal of Biological Sciences
سال: 2016
ISSN: 1449-2288
DOI: 10.7150/ijbs.16176